Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.Nedsatt konsentrasjon av aktiv metabolitt av kodein, risiko for nedsatt analgetisk effekt av kodein (fremfor alt med tanke på at pasienter som bruker metadon allerede har utviklet opioidtoleranse).Det har blitt rapportert o

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